ROLE OF GLYCOSAMINOGLYCANS IN DIABETIC NEPHROPATHY

被引:24
作者
GAMBARO, G [1 ]
BAGGIO, B [1 ]
机构
[1] UNIV PADUA, SCH MED,INST INTERNAL MED,DIV NEPHROL, VIA GIUSTINIANI 2, I-35128 PADUA, ITALY
关键词
DIABETIC NEPHROPATHY; GLOMERULAR BASEMENT MEMBRANE; GROWTH FACTORS; GLYCOSAMINOGLYCANS; HEPARAN SULFATE;
D O I
10.1007/BF00573480
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A number of abnormalities of glycosaminoglycan metabolism have been reported in diabetes mellitus. These include anomalous synthesis, catabolism and sulphation. In this review glycosaminoglycan metabolism in diabetes mellitus is discussed with reference to its possible impact on glomerular basement membrane permeability, and on the physiology and metabolism of glomerular resident cells, specifically of the mesangium. Experimental results demonstrating favourable therapeutic activities of some glycosaminoglycans in mesangioproliferative glomerulitis and diabetic nephropathy are reported. These pharmacological actions do not depend on the well-known anticoagulative activity of glycosaminoglycans, but most probably on their antiproliferative effect. A more complex role of glycosaminoglycans in the pathogenesis of diabetic nephropathy is suggested.
引用
收藏
页码:149 / 155
页数:7
相关论文
共 88 条