COMPARATIVE OTOTOXICITY OF CISPLATIN DURING ACUTE AND CHRONIC TREATMENT

被引：47

作者：

SAITO, T

ARAN, JM

机构：

[1] Department of Otolaryngology, Fukui Medical School, Fukui

[2] Laboratoire d’Audiologie Expérimentale, INSERM 229, Université de Bordeaux-II, Bordeaux

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1994年 / 56卷 / 06期

关键词：

CISPLATIN; OTOTOXICITY; COMPOUND ACTION POTENTIAL; COCHLEOGRAM; TRANSMISSION ELECTRON MICROSCOPY;

D O I：

10.1159/000276683

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Functional and morphological alterations were compared in guinea pig cochleae treated acutely (7.5 mg/kg x 2) and chronically (1.5 mg/kg x 10) with cisplatin. Drastic and rapid hearing impairments using compound action potential were observed only after the second injection during acute treatment. During chronic treatment, threshold changes were observed abruptly after 8 or 9 days of treatment. Morphological changes of outer hair cells were stronger in the acute treatment than the chronic one, and they appeared to concur with the functional data. Partial damage in the stria vascularis was observed only after acute treatment. From these results, it was suspected that acute and chronic ototoxic mechanisms differed according to the pharmacokinetics of cisplatin in the inner ear fluid and tissues.

引用

页码：315 / 320

页数：6

共 23 条

[11] Aran J.M., Erre J.P., Hiel H., De Charlet Sauvage R., Goeury P., Pounet J.F., Investigation of cochlear mechanisms using combined acoustical and electrical stimulations, Scand Audiol, pp. 63-69, (1986)
[12] Boheim K., Bichler E., Cisplatin-induced ototoxicity: Audiometric findings and experimental cochlear pathology, Arch Otorhinolaryngol, 242, pp. 1-6, (1985)
[13] Marco-Algarra J., Basterra J., Marco J., Cisdiamminedichloroplatinum ototoxicity, Acta Otolaryngol (Stockh), 99, pp. 343-347, (1985)
[14] Kimitsuki T., Nakagawa T., Hisa K., Komune S., Blocking mechanism of cisplatin on transducer current of cochlear hair cells of chick, Otol Jpn, 3, (1993)
[15] Saito T., Moataz R., Dulon D., Cisplatin blocks depolarization-induced calcium entry in isolated cochlear outer hair cells, Hear Res, 56, pp. 143-147, (1991)
[16] Komune S., Snow J.B., Potentiating effects of cisplatin and ethacrynic acid in ototoxicity, Arch Otolaryngol, 107, pp. 594-597, (1981)
[17] Laurell G., Engstroxm B., The combined effect of cisplatin and furosemide on hearing function in guinea pigs, Hear Res, 38, pp. 19-26, (1989)
[18] Tange R.A., Vuzevski V.D., Changes in the stria vascularis of the guinea pig due to m-platinum, Arch Otolaryngol, 239, pp. 41-47, (1984)
[19] Kohn S., Fradis M., Pratt H., Zidan J., Podoshin L., Robinson E., Nir I., Cisplatin ototoxicity in guinea pigs with special reference to toxic effects in the stria vascularis, Laryngoscope, 98, pp. 865-871, (1988)
[20] Barron S.E., Daigncault E.A., Effect of cisplatin on hair cell morphology and lateral wall Na, K-ATPase activity, Hear Res, 26, pp. 131-137, (1987)

← 1 2 3 →