2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINES .2. 2-(4-CARBAMOYLPIPERIDINO) DERIVATIVES AS ALPHA-1-ADRENOCEPTOR ANTAGONISTS AND ANTIHYPERTENSIVE AGENTS

被引：30

作者：

ALABASTER, VA

CAMPBELL, SF

DANILEWICZ, JC

GREENGRASS, CW

PLEWS, RM

机构：

[1] PFIZER LTD,CENT RES,DEPT DISCOVERY CHEM,SANDWICH,KENT,ENGLAND

[2] PFIZER LTD,CENT RES,DEPT DISCOVERY BIOL,SANDWICH,KENT,ENGLAND

来源：

关键词：

D O I：

10.1021/jm00389a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：999 / 1003

页数：5

共 14 条

[1] FUNCTIONAL-GROUPS, DRUG RECEPTOR INTERACTIONS AND DRUG DESIGN
ANDREWS, P
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (04) : 148 - 151
[2] BORDNER J, UNPUB
[3] Campbell S F, 1986, Drug Des Deliv, V1, P83
[4] 2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINES .1. 2-[4-(1,4-BENZODIOXAN-2-YLCARBONYL)PIPERAZIN-1-YL] DERIVATIVES AS ALPHA-1-ADRENOCEPTOR ANTAGONISTS AND ANTIHYPERTENSIVE AGENTS
CAMPBELL, SF
DAVEY, MJ
HARDSTONE, JD
LEWIS, BN
PALMER, MJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (01) : 49 - 57
[5] CAMPBELL SF, 1984, XRAY CRYSTALLOGRAPHY, P347
[6] CAMPBELL SF, Patent No. 2021108
[7] CAMPBELL SF, 1984, 2ND SCI RSC MED CHEM, P18
[8] CLINICAL PHARMACOLOGICAL STUDIES WITH DOXAZOSIN
ELLIOTT, HL
MEREDITH, PA
VINCENT, J
REID, JL
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 21 : S27 - S31
[9] FERSHT A, 1985, ENZYME STRUCTURE MEC, P299
[10] GRAHAM RM, 1984, AM J CARDIOL, V53, pA16, DOI 10.1016/0002-9149(84)90829-4