TRITIUM LABELING OF CYPRODIME (=(-)-17-(CYCLOPROPYLMETHYL)-4,14-DIMETHOXYMORPHINAN-6-ONE), A MU-RECEPTOR-SELECTIVE OPIOID ANTAGONIST

被引：17

作者：

OTVOS, F

TOTH, G

SCHMIDHAMMER, H

机构：

[1] HUNGARIAN ACAD SCI,BIOL RES CTR,ISOTOPE LAB,H-6701 SZEGED,HUNGARY

[2] UNIV INNSBRUCK,INST ORGAN & PHARMACEUT CHEM,A-6020 INNSBRUCK,AUSTRIA

来源：

HELVETICA CHIMICA ACTA | 1992年 / 75卷 / 05期

关键词：

D O I：

10.1002/hlca.19920750524

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of [1-H-3]cyprodime (2), which has a specific activity of 31.6 Ci/mmol was carried out by catalytic tritiodehalogenation of 1-bromocyprodime (3). Bromination of cyprodime was performed by using chloroperoxidase, KBr, and H2O2.

引用

页码：1718 / 1720

页数：3

共 6 条

[1]

DAVIES SG, 1989, HETEROCYCLES, V28, P163

[2] SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS .3. EXTENSIVE STUDY ON CYPRODIME-RELATED COMPOUNDS [J].

SCHMIDHAMMER, H ;

SMITH, CFC ;

ERLACH, D ;

KOCH, M ;

KRASSNIG, R ;

SCHWETZ, W ;

WECHNER, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (04) :1200-1206

[3] SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS .2. (-)-N-(CYCLOPROPYLMETHYL)-4,14-DIMETHOXYMORPHINAN-6-ONE, A SELECTIVE MU-OPIOID RECEPTOR ANTAGONIST [J].

SCHMIDHAMMER, H ;

BURKARD, WP ;

EGGSTEINAEPPLI, L ;

SMITH, CFC .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :418-421

[4]

SCHMIDHAMMER H, 1989, TRENDS MED CHEM 88

[5]

STANLEY WL, 1957, J ASSOC OFF AGR CHEM, V40, P282

[6]

Toth G, 1981, IZOTOPTECHNIKA BUDAP, V24, P259

← 1 →