COMPARATIVE MAPPING OF 50 HUMAN-CHROMOSOME-9 LOCI IN THE LABORATORY MOUSE

被引：33

作者：

PILZ, A

WOODWARD, K

POVEY, S

ABBOTT, C

机构：

[1] UNIV LONDON UNIV COLL, MRC, HUMAN BIOCHEM GENET UNIT, LONDON NW1 2HE, ENGLAND

[2] WESTERN GEN HOSP, MRC, HUMAN GENET UNIT, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

来源：

GENOMICS | 1995年 / 25卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(95)80119-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have set out to produce a comprehensive comparative map between human chromosome 9 (HSA9) and the laboratory mouse. The mouse homologues of 50 loci that were known to map to HSA9 were mapped by interspecific backcross linkage analysis. Ten loci from the short arm of HSA9 were mapped, and 40 from HSA9q, with 24 markers coming from the HSA9q33-q34 region - a part of the chromosome known to be very gene rich. Fifteen new assignments have been made - Ak3, Ctsl, Cntfr, C8g, D2H9S46E, Eng, Gcnt1, Irebp, Pappa, Ptgds, Snf2l2, Tal2, Tmod, Vav2, and Vldlr, the human homologues of which all map to HSA9. In addition, the assignment of Snf2l2 and Vldlr to MMU19 has defined a new region of synteny between the proximal portion of the short arm of HSA9 and the mouse. (C) 1995 Academic Press, Inc.

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页码：139 / 149

页数：11

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