STRUCTURE-ACTIVITY CORRELATIONS FOR A SERIES OF ANTIALLERGY AGENTS - OXANILIC, QUINALDIC, AND BENZOPYRAN-2-CARBOXYLIC ACIDS

被引：19

作者：

CHENEY, BV ^{[1
]}

WRIGHT, JB ^{[1
]}

HALL, CM ^{[1
]}

JOHNSON, HG ^{[1
]}

CHRISTOFFERSEN, RE ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66044

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1978年 / 21卷 / 09期

关键词：

D O I：

10.1021/jm00207a017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ab initio Hartree-Fock SCF calculations with the molecular fragment technique have been performed on several drugs which exhibit activity in the rat passive cutaneous anaphylaxis (PCA) assay. Representative molecules of the following types were included in the series: oxanilic acids, l,4-dihydro-4-oxoquinaldic acids, and 4-oxo-4H-l-benzopyran-2-carboxylic acids. A quantitative relationship has been established between the observed biological activity and an electronic index obtained from the calculations. The correlation is rationalized in terms of charge-transfer stabilization of the drug-receptor complex. © 1978, American Chemical Society. All rights reserved.

引用

页码：936 / 940

页数：5

共 28 条

[21] XANTHONE-2-CARBOXYLIC ACIDS, A NEW SERIES OF ANTIALLERGIC SUBSTANCES [J].