IDENTIFICATION OF A 110-KDA NONINTEGRIN CELL-SURFACE LAMININ-BINDING PROTEIN WHICH RECOGNIZES AN A CHAIN NEURITE-PROMOTING PEPTIDE

被引:115
作者
KLEINMAN, HK
WEEKS, BS
CANNON, FB
SWEENEY, TM
SEPHEL, GC
CLEMENT, B
ZAIN, M
OLSON, MOJ
JUCKER, M
BURROUS, BA
机构
[1] VANDERBILT UNIV,SCH MED,LAB SERV,NASHVILLE,TN 37203
[2] HOSP PONTCHAILLOU,INSERM,U49,F-35033 RENNES,FRANCE
[3] UNIV MISSISSIPPI,MED CTR,DEPT BIOCHEM,JACKSON,MS 39216
[4] NIA,CELLULAR & MOLEC BIOL LAB,BALTIMORE,MD 21224
[5] US PATENT & TRADEMARK OFF,ARLINGTON,VA 22202
关键词
D O I
10.1016/0003-9861(91)90547-V
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Laminin is a potent promoter of neurite outgrowth, and a synthetic peptide of 19 amino acids, PA22-2, from the A chain has been found to promote process formation. Using peptide affinity chromatography, we have identified a 110-kDa, cell surface ligand from both neural cells and brain which binds this sequence. This binding protein does not share immunological identity with the B1 chain of integrin, and reduction does not alter its mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Antibody to the 110-kDa protein stained cellular processes in vivo. Sequence analysis of the first 18 amino acids from the amino terminus yielded almost exact sequence identity with nucleolin, a major 110-kDa nucleolar phosphoprotein. Antibody to nucleolin, however, does not interact with the neural-derived, laminin-peptide-binding 110-kDa protein. The 110-kDa protein appears to be a ligand for a specific site on laminin. © 1991.
引用
收藏
页码:320 / 325
页数:6
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