PHARMACOKINETICS OF CONCOMITANTLY ADMINISTERED FOSCARNET AND ZIDOVUDINE FOR TREATMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION (AIDS CLINICAL-TRIALS GROUP PROTOCOL-053)

被引：16

作者：

AWEEKA, FT

GAMBERTOGLIO, JG

VANDERHORST, C

RAASCH, R

JACOBSON, MA

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV N CAROLINA,DEPT MED,CHAPEL HILL,NC 27599

[3] UNIV N CAROLINA,SCH PHARM,CHAPEL HILL,NC 27599

[4] SAN FRANCISCO GEN HOSP,MED SERV,SAN FRANCISCO,CA 94110

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 08期

关键词：

D O I：

10.1128/AAC.36.8.1773

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Foscarnet and zidovudine (ZDV) pharmacokinetic parameters were not altered in five patients receiving 14 days of concomitant therapy. Foscarnet clearance in plasma averaged (+/- standard deviation) 0.16 +/- 0.03 and 0.13 +/- 0.05 liter/h/kg of body weight in the absence and presence of ZDV. ZDV parameters were also not significantly altered, with a mean (+/- standard deviation) oral clearance of 2.7 +/- 1.0 and 2.6 +/- 0.8 liter/h/kg for the 2 study days, respectively.

引用

页码：1773 / 1778

页数：6

共 20 条

[1] PHARMACOKINETICS OF INTERMITTENTLY ADMINISTERED INTRAVENOUS FOSCARNET IN THE TREATMENT OF ACQUIRED IMMUNODEFICIENCY SYNDROME PATIENTS WITH SERIOUS CYTOMEGALO-VIRUS RETINITIS
AWEEKA, F
GAMBERTOGLIO, J
MILLS, J
JACOBSON, MA
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (05) : 742 - 745
[2] CHRISP P, 1991, DRUGS, V41, P102
[3] CLINICAL PHARMACOKINETICS OF ZIDOVUDINE - AN OVERVIEW OF CURRENT DATA
COLLINS, JM
UNADKAT, JD
[J]. CLINICAL PHARMACOKINETICS, 1989, 17 (01) : 1 - 9
[4] COMBINATIONS OF 3'-AZIDO-3'-DEOXYTHYMIDINE (ZIDOVUDINE) AND PHOSPHONOFORMATE (FOSCARNET) AGAINST HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 AND CYTOMEGALO-VIRUS REPLICATION INVITRO
ERIKSSON, BFH
SCHINAZI, RF
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (05) : 663 - 669
[5] FLETCHER CV, 1990, 30TH INT C ANT AG CH
[6] Gibaldi M., 1984, BIOPHARMACEUTICS CLI, P17
[7] SIMULTANEOUS QUANTIFICATION OF ZIDOVUDINE AND ITS GLUCURONIDE IN SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
GOOD, SS
REYNOLDS, DJ
DEMIRANDA, P
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 431 (01): : 123 - 133
[8] DETERMINATION OF PHOSPHONOFORMIC ACID IN HUMAN PLASMA AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION
HASSANZADEH, MK
AWEEKA, FT
WU, S
JACOBSON, MA
GAMBERTOGLIO, JG
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 525 (01): : 133 - 140
[9] FOSCARNET TREATMENT OF CYTOMEGALO-VIRUS RETINITIS IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME
JACOBSON, MA
ODONNELL, JJ
MILLS, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (05) : 736 - 741
[10] INVIVO ADDITIVE ANTIRETROVIRAL EFFECT OF COMBINED ZIDOVUDINE AND FOSCARNET THERAPY FOR HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION (ACTG PROTOCOL 053)
JACOBSON, MA
VANDERHORST, C
CAUSEY, DM
DEHLINGER, M
HAFNER, R
MILLS, J
[J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06) : 1219 - 1222

← 1 2 →