PHARMACOKINETICS OF CONCOMITANTLY ADMINISTERED FOSCARNET AND ZIDOVUDINE FOR TREATMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION (AIDS CLINICAL-TRIALS GROUP PROTOCOL-053)

被引：16

作者：

AWEEKA, FT

GAMBERTOGLIO, JG

VANDERHORST, C

RAASCH, R

JACOBSON, MA

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV N CAROLINA,DEPT MED,CHAPEL HILL,NC 27599

[3] UNIV N CAROLINA,SCH PHARM,CHAPEL HILL,NC 27599

[4] SAN FRANCISCO GEN HOSP,MED SERV,SAN FRANCISCO,CA 94110

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 08期

关键词：

D O I：

10.1128/AAC.36.8.1773

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Foscarnet and zidovudine (ZDV) pharmacokinetic parameters were not altered in five patients receiving 14 days of concomitant therapy. Foscarnet clearance in plasma averaged (+/- standard deviation) 0.16 +/- 0.03 and 0.13 +/- 0.05 liter/h/kg of body weight in the absence and presence of ZDV. ZDV parameters were also not significantly altered, with a mean (+/- standard deviation) oral clearance of 2.7 +/- 1.0 and 2.6 +/- 0.8 liter/h/kg for the 2 study days, respectively.

引用

页码：1773 / 1778

页数：6

共 20 条

[11] JACOBSON MA, 1988, J INFECT DIS, V158, P862, DOI 10.1093/infdis/158.4.859
[12] MAINTENANCE THERAPY FOR CYTOMEGALOVIRUS RETINITIS IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME - FOSCARNET
JACOBSON, MA
[J]. AMERICAN JOURNAL OF MEDICINE, 1992, 92 : S26 - S29
[13] INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS INVITRO BY COMBINATIONS OF 3'-AZIDO-3'-DEOXYTHYMIDINE AND FOSCARNET
KOSHIDA, R
VRANG, L
GILLJAM, G
HARMENBERG, J
OBERG, B
WAHREN, B
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (05) : 778 - 780
[14] DETERMINATION OF PHOSPHONOFORMATE (FOSCARNET) IN BIOLOGICAL-FLUIDS BY ION-PAIR REVERSED-PHASE LIQUID-CHROMATOGRAPHY
PETTERSSON, KJ
NORDGREN, T
WESTERLUND, D
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 488 (02): : 447 - 455
[15] SANDSTROM EG, 1985, LANCET, V1, P1480
[16] ZIDOVUDINE DISPOSITION IN PATIENTS WITH SEVERE RENAL IMPAIRMENT - INFLUENCE OF HEMODIALYSIS
SINGLAS, E
PIOGER, JC
TABURET, AM
COLIN, JN
FILLASTRE, JP
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1989, 46 (02) : 190 - 197
[17] SJOVALL J, 1988, CLIN PHARMACOL THER, V44, P65
[18] PHARMACOKINETICS OF FOSCARNET AND DISTRIBUTION TO CEREBROSPINAL-FLUID AFTER INTRAVENOUS-INFUSION IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS-INFECTION
SJOVALL, J
BERGDAHL, S
MOVIN, G
OGENSTAD, S
SAARIMAKI, M
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (07) : 1023 - 1031
[19] PHARMACOKINETICS OF ORAL ZIDOVUDINE (AZIDOTHYMIDINE) IN PATIENTS WITH AIDS WHEN ADMINISTERED WITH AND WITHOUT A HIGH-FAT MEAL
UNADKAT, JD
COLLIER, AC
CROSBY, SS
CUMMINGS, D
OPHEIM, KE
COREY, L
[J]. AIDS, 1990, 4 (03) : 229 - 232
[20] COMPETITIVE-INHIBITION OF ZIDOVUDINE CLEARANCE BY PROBENECID DURING CONTINUOUS COADMINISTRATION
WONG, SL
HEDAYA, MA
SAWCHUK, RJ
[J]. PHARMACEUTICAL RESEARCH, 1992, 9 (02) : 228 - 235

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