ALKYLATION OF ALPHA-TERT-BUTOXYCARBONYLAMINO KETONE ENOLATE ANIONS - A USEFUL SYNTHESIS OF ALPHA-ALKYL-ALPHA-AMINO KETONES, 2-ACYLPYRROLIDINES, AND 2-ACYLPIPERIDINES

被引：11

作者：

GUZMAN, A

QUINTFRO, C

MUCHOWSKI, JM

机构：

[1] SYNTEX INC,RES,INST ORGAN CHEM,3401 HILLVIEW AVE,PALO ALTO,CA 94304

[2] SYNTEX SA CV,DIV INVEST,MEXICO CITY 10,DF,MEXICO

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1991年 / 69卷 / 12期

关键词：

ALPHA-TERT-BUTOXYCARBONYLAMINO KETONES; ALPHA-ALKYL-ALPHA-AMINO KETONES; 2-ACYLPYRROLIDINES; AND; 2-ACYLPIPERIDINES;

D O I：

10.1139/v91-298

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile synthesis of alpha-alkyl-alpha-amino ketones 5 and cyclic alpha-amino ketones 7 based on the selective mono-alpha-alkylation and C(alpha), N-cycloalkylation of alpha-tert-butoxycarbonylamino ketones 2 and subsequent acidic hydrolysis is described.

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收藏

页码：2059 / 2063

页数：5

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