CHANGES IN THE CONCENTRATIONS OF TAU AND OTHER STRUCTURAL PROTEINS IN THE BRAINS OF AGED MICE

被引：11

作者：

BAHR, BA

LAM, N

LYNCH, G

机构：

[1] Center for the Neurobiology of Learning and Memory, Bonney Center, University of California, Irvine

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

关键词：

AGE; BRAIN; TAU; ANKYRIN; SPECTRIN; ACTIN; NEUROFILAMENT; TALIN;

D O I：

10.1016/0304-3940(94)91075-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To test whether aging is associated with alterations in the balance of cytoskeletal constituents, the relative concentrations of tau isoforms and seven other structural proteins were compared in the brains of 3-25-month-old mice. A tau species of approx. 63kDa was substantially increased in the older animals while the levels of ankyrin, talin, spectrin, and actin were differentially decreased, The decrement in ankyrin was evident at earlier ages than that for spectrin. These results suggest that The make-up of the neuronal cytoskeleton changes with age.

引用

页码：49 / 52

页数：4

共 19 条

[11]

Kemper TL, 1984, CLIN NEUROLOGY AGING, P9

[12] BRAIN LEVELS OF MICROTUBULE-ASSOCIATED PROTEIN-TAU ARE ELEVATED IN ALZHEIMERS-DISEASE - A RADIOIMMUNO-SLOT-BLOT ASSAY FOR NANOGRAMS OF THE PROTEIN [J].