THE RELATIONSHIP BETWEEN NUTRITIONAL-STATUS AND SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR CONCENTRATIONS IN PATIENTS WITH CROHNS-DISEASE TREATED WITH ELEMENTAL DIET

被引：4

作者：

DUANE, PD

TEAHON, K

CRABTREE, JE

LEVI, AJ

HEATLEY, RV

BJARNASON, I

机构：

[1] Department of Medicine, St. James's University Hospital, Leeds

[2] Gastroenterology Department, Northwick Park Hospital, Harrow, Middlesex

来源：

CLINICAL NUTRITION | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1016/0261-5614(91)90042-B

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Serum soluble interleukin-2 receptor concentrations (sIL-2R) were measured and correlated with indices of disease activity and nutrition in 13 patients with active Crohn's disease treated with an elemental diet. The initial serum sIL-2R concentrations were raised, 1121 +/- 181 U/ml (mean +/- SEM) compared to controls, 177 +/- 22.9 U/ml (n = 18) (p < 0.001). Four weeks' treatment resulted in significant improvement in disease activity (Harvey-Bradshaw index) and 4-day faecal Indium-111-leucocyte excretion. Serum sIL-2R concentrations did not change significantly after treatment, 789 +/- 79.8 U/ml (p > 0.05). Serum sIL-2R concentrations were inversely correlated with albumin, pre-albumin, creatinine-height index and total body potassium. Only those patients with markedly elevated sIL-2R concentrations (> 800 U/ml) and severe nutritional depletion prior to treatment, showed significant reductions in sIL-2R levels with elemental dietary treatment. These results demonstrate an association between nutritional impairment and immune activation in Crohn's disease.

引用

页码：222 / 227

页数：6

共 28 条

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