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A NOVEL METALLOPROTEINASE GENE SPECIFICALLY EXPRESSED IN STROMAL CELLS OF BREAST CARCINOMAS

被引：1095
作者：
BASSET, P
BELLOCQ, JP
WOLF, C
STOLL, I
HUTIN, P
LIMACHER, JM
PODHAJCER, OL
CHENARD, MP
RIO, MC
CHAMBON, P
机构：
[1] FAC MED STRASBOURG, INST CHIM BIOL,INSERM, UNITE BIOL MOLEC & GEN GENET 184,CNRS, F-67085 STRASBOURG, FRANCE
[2] CHU STRASBOURG, SERV ANAT PATHOL GEN, F-67098 STRASBOURG, FRANCE
来源：
NATURE | 1990年 / 348卷 / 6303期
关键词：
D O I：
10.1038/348699a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies. © 1990 Nature Publishing Group.
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页码：699 / 704
页数：6
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