EFFECT OF SENNA IS NOT MEDIATED BY PLATELET-ACTIVATING-FACTOR

被引:5
作者
CAPASSO, F
IZZO, AA
MASCOLO, N
AUTORE, G
DICARLO, G
机构
[1] Department of Experimental Pharmacology, University of Naples ‘Federico II’, Naples
关键词
SENNA; RHEIN; RHEIN ANTHRONE; PHENOLPHTHALEIN; BILE SALTS; MAGNESIUM SULFATE; INTESTINE; PLATELET-ACTIVATING FACTOR; ACID PHOSPHATASE;
D O I
10.1159/000139843
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of in vivo treatment with senna was examined on the ex vivo formation of platelet-activating factor (PAF) by small and large intestine of rat, mouse and guinea pig. A single or a prolonged oral administration of senna (60-240 mg/kg) to animals did not increase intestinal PAF content. Nor did senna increase the intraluminal release of acid phosphatase. A similar result was obtained in the colonic tissue of rat perfused in vitro with rhein (1-500 mug/ml) or rhein anthrone (1-500 mug/ml). In contrast, a single oral administration of phenolphthalein (20 mg/kg), bile salts (20 mg/kg) or magnesium sulfate (30 mg/kg) to rats increased intestinal PAF content. Magnesium sulfate also increased the intraluminal release of acid phosphatase. Colonic tissue of rats perfused in vitro with calcium ionophore A23187 (10 mug/ml) formed large amounts of PAF and acid phosphatase. PAF stimulates intestinal motility and secretion and mediates gut damage while acid phosphatase is a marker of cellular damage. Therefore, our data suggest that senna is well tolerated in animals and PAF does not mediate senna-induced laxation.
引用
收藏
页码:58 / 63
页数:6
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