A SIMPLIFIED SYNTHESIS OF (+)-BREFELDIN-A

被引：46

作者：

COREY, EJ

CARPINO, P

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 52期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)97297-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective and enantioselective process for the total synthesis of (+)-brefeldin A (1) is described which starts from the dextrorotatory ketone 2.

引用

页码：7555 / 7558

页数：4

共 26 条

[11] ELECTROPHILIC BROMINATION OF BICYCLO[3,3,0]HEPT-2-EN-6-ONES [J].

GRUDZINSKI, Z ;

ROBERTS, SM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (18) :1767-1773

[12] SYNTHESIS OF MACRO-CYCLIC AND MEDIUM-CYCLIC COMPOUNDS .4. STEREOSLECTIVE TOTAL SYNTHESIS OF (+)-BREFELDIN-A [J].

KITAHARA, T ;

MORI, K .

TETRAHEDRON, 1984, 40 (15) :2935-2944

[13]

KOEKSAL Y, 1980, Angewandte Chemie International Edition in English, V19, P472

[14] EFFICIENT STEREOCONTROLLED TOTAL SYNTHESES OF RACEMIC AND NATURAL BREFELDIN-A [J].

LEDRIAN, C ;

GREENE, AE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (20) :5473-5483

[15] BLOCKADE BY BREFELDIN A OF INTRACELLULAR-TRANSPORT OF SECRETORY PROTEINS IN MOUSE PITUITARY-CELLS - EFFECTS ON THE BIOSYNTHESIS OF THYROTROPIN AND FREE ALPHA-SUBUNITS [J].

MAGNER, JA ;

PAPAGIANNES, E .

ENDOCRINOLOGY, 1988, 122 (03) :912-920

[16]

MISUMI Y, 1986, J BIOL CHEM, V261, P1398

[17]

PERKEL VS, 1989, P SOC EXP BIOL MED, V190, P286

[18] A NOVEL SYNTHESIS OF CIS-3,4-DISUBSTITUTED CYCLOPENTANONES [J].

SAKAI, K ;

ISHIGURO, Y ;

FUNAKOSHI, K ;

UENO, K ;

SUEMUNE, H .

TETRAHEDRON LETTERS, 1984, 25 (09) :961-964

[19] NICKEL-CATALYZED CONJUGATE ADDITION OF ALKENYL ZIRCONIUM SPECIES TO ALPHA,BETA-UNSATURATED KETONES [J].

SCHWARTZ, J ;

LOOTS, MJ ;

KOSUGI, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (04) :1333-1340

[20] KONSTITUTION VON BREFELDIN A [J].

SIGG, HP .

HELVETICA CHIMICA ACTA, 1964, 47 (06) :1401-&

← 1 2 3 →