CYTOKINE RECEPTOR SIGNAL-TRANSDUCTION MECHANISMS IN IMMUNO-HEMATOPOIETIC CELLS

被引：1

作者：

CHIARUGI, V

DELLOSBARBA, P

MAGNELLI, L

CHIARUGI, P

PACINI, S

RUGGIERO, M

机构：

[1] UNIV FLORENCE,INST GEN PATHOL,I-50121 FLORENCE,ITALY

[2] UNIV FLORENCE,DEPT BIOCHEM SCI,BIOTECHNOL LAB,I-50121 FLORENCE,ITALY

来源：

TUMORI | 1993年 / 79卷 / 02期

关键词：

IMMUNO-HEMATOPOIESIS; CELL SIGNALING; CYTOKINE RECEPTORS; TYROSINE PHOSPHORYLATION;

D O I：

10.1177/030089169307900202

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Novel aspects of cytokine receptor signal transduction are discussed and cytokine receptors classified based on ligand-dependent signalling. An introductory section presents an overview of the role of cytokines in hematopoiesis. A brief explanation of basic concepts, such as redundancy, pleiotropy, synergism, etc., important for the understanding of cell response to cytokines, is also included. Three of five classes of receptors show the involvement of tyrosine kinase activity as the key step in signal transduction. The importance of tyrosine phosphorylation in cellular response to cytokines is pointed out.

引用

收藏

页码：92 / 99

页数：8

相关论文

共 44 条

[31] ASSOCIATION OF THE FYN PROTEIN-TYROSINE KINASE WITH THE T-CELL ANTIGEN RECEPTOR [J].

SAMELSON, LE ;

PHILLIPS, AF ;

LUONG, ET ;

KLAUSNER, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) :4358-4362

[32] INVOLVEMENT OF RAS P21 PROTEIN IN SIGNAL-TRANSDUCTION PATHWAYS FROM INTERLEUKIN-2, INTERLEUKIN-3, AND GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR, BUT NOT FROM INTERLEUKIN-4 [J].

SATOH, T ;

NAKAFUKU, M ;

MIYAJIMA, A ;

KAZIRO, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3314-3318

[33]

SCHOFIELD R, 1978, BLOOD CELLS, V4, P7

[34] RESTING AND ACTIVATED SUBSETS OF MOUSE MULTIPOTENT HEMATOPOIETIC STEM-CELLS [J].

SPANGRUDE, GJ ;

JOHNSON, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7433-7437

[35]

TAOLIN Y, 1992, MOL CELL BIOL, V12, P836

[36]

TAOLIN Y, 1991, MOL CELL BIOL, V11, P2391

[37]

TONKS N K, 1988, Biochemistry, V27, P8695, DOI 10.1021/bi00424a001

[38] THE CD4 AND CD8 T-CELL SURFACE-ANTIGENS ARE ASSOCIATED WITH THE INTERNAL MEMBRANE TYROSINE-PROTEIN KINASE P56LCK [J].

VEILLETTE, A ;

BOOKMAN, MA ;

HORAK, EM ;

BOLEN, JB .

CELL, 1988, 55 (02) :301-308

[39] ENGAGEMENT OF CD4 AND CD8 EXPRESSED ON IMMATURE THYMOCYTES INDUCES ACTIVATION OF INTRACELLULAR TYROSINE PHOSPHORYLATION PATHWAYS [J].

VEILLETTE, A ;

ZUNIGAPFLUCKER, JC ;

BOLEN, JB ;

KRUISBEEK, AM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1671-1680

[40] INTERLEUKIN-7 RECEPTOR FUNCTIONS BY RECRUITING THE TYROSINE KINASE P59(FYN) THROUGH A SEGMENT OF ITS CYTOPLASMIC TAIL [J].

VENKITARAMAN, AR ;

COWLING, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :12083-12087

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