PLATELET-AGGREGATION OF MIGRAINEURS DURING AND BETWEEN ATTACKS

被引：40

作者：

KOVACS, K

HERMAN, F

FILEP, J

JELENCSIK, I

MAGYAR, K

机构：

[1] Institute of Neurology, Budapest

[2] Department of Pharmacodynamics, Budapest

[3] Department of Pathophysiology, Semmelweis Medical University, Budapest

来源：

CEPHALALGIA | 1990年 / 10卷 / 04期

基金：

匈牙利科学研究基金会;

关键词：

ADP; collagen; migraine; platelet aggregation; platelet-activating factor;

D O I：

10.1046/j.1468-2982.1990.1004161.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Platelet aggregation induced by ADP, collagen and platelet-activating factor was studied in common (migraine without aura) and classical migraine (migraine with aura) patients during and between attacks. The E.C., 50* values for ADP and platelet-activating factor were significantly higher, whilst that for collagen was significantly lower in classical migraine patients during headache-free intervals compared to healthy volunteers. The E.C., 50values obtained for common migraine sufferers during symptom-free periods were similar to those of controls. During attacks, the EC 50 value for ADP, but not for collagen and platelet-activating factor, was significantly higher than that of the controls. In healthy subjects a positive correlation was found between ADP and collagen-induced aggregation. In contrast, there was a U-shaped correlation matrix in classical migraine patients. The present observations show that platelet aggregation is altered in migraine patients and this raises the possibility that platelet-activating factor may be involved in the pathogenesis of migraine. © 1990, International Headache Society. All rights reserved.

引用

页码：161 / 165

页数：5

共 18 条

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