LESIONS OF THE SUPRACHIASMATIC NUCLEUS DISRUPT CIRCADIAN LOCOMOTOR RHYTHMS IN THE MOUSE

被引：43

作者：

SCHWARTZ, WJ

ZIMMERMAN, P

机构：

[1] Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655

来源：

PHYSIOLOGY & BEHAVIOR | 1991年 / 49卷 / 06期

关键词：

SUPRACHIASMATIC NUCLEUS; CIRCADIAN RHYTHM; BALB/C MICE; WHEEL-RUNNING; LIGHT-DARK CYCLE;

D O I：

10.1016/0031-9384(91)90364-T

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Entrained and free-running rhythms of wheel-running activity were recorded in male BALB/cByJ mice with electrolytic lesions of the suprachiasmatic nucleus (SCN), site of a circadian pacemaker in mammals. Complete ablation of the nucleus abolished the circadian locomotor rhythm; in some cases, wheel-running was synchronized by a light-dark cycle, but the phase relationship of this activity to the cycle was often aberrant. Unilateral lesions or those missing the SCN did not eliminate rhythmicity.

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页码：1283 / 1287

页数：5

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