INTRAPERITONEAL INJECTION OF 1-OLEOYL-2-DOCOSAHEXAENOYL PHOSPHATIDYLCHOLINE ENHANCES DISCRIMINATORY SHOCK AVOIDANCE-LEARNING IN RATS

被引：4

作者：

IZAKI, Y ^{[1
]}

HASHIMOTO, M ^{[1
]}

ARITA, J ^{[1
]}

IRIKI, M ^{[1
]}

HIBINO, H ^{[1
]}

机构：

[1] NOF CORP, TSUKUBA RES LAB, IBARAKI, OSAKA, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 167卷 / 1-2期

关键词：

PHOSPHATIDYLCHOLINE; 1-OLEOYL-2-DOCOSAHEXAENOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE; ACETYLCHOLINE; DOCOSAHEXAENOATE; LEARNING;

D O I：

10.1016/0304-3940(94)91054-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of injection of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (ODHPC) on learning ability were investigated in rats using discriminatory shock avoidance learning task. When ODHPC (2 mu mol) was intraperitonealy administered 5 min before the beginning of the first trial of learning task from the second to fifth sessions, avoiding rates of the ODHPC-injected group were significantly higher than those of the control group. However, any injection of ODHPC derivatives, such as 1-oleoyl-2-docosahexaenoyl-diacylglycerol, 1,2-dioleoyl-sn-glycero-3-phosphorylcholine, glycerophosphorylcholine, docosahexaenoate, oleate and choline chloride, did not affect learning. These results suggest that intraperitoneal ODHPC injection enhances learning ability by its specific conformation.

引用

页码：171 / 174

页数：4

共 18 条

[1]

BENINGER RJ, 1989, ARCH GERONTOL GERIAT, P71

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