THEOPHYLLINE ANTAGONIZES FLURAZEPAM-INDUCED DEPRESSION OF CEREBRAL CORTICAL-NEURONS

Intravenously administered theophylline (50-100 mg/kg) antagonized the depressent actions of adenosine and flurazepam on rat cerebral cortical neurons. When assessed in conjunction with recent reports that theophylline competes with diazepam for binding sites in brain tissue, this finding suggests that one action of the benzodiazepines may be exerted at a purinergic receptor associated with central neurons.