A WITHIN-SUBJECT ANALYSIS OF CARBAMAZEPINE DISPOSITION RELATED TO DEVELOPMENT IN CHILDREN WITH EPILEPSY

被引：11

作者：

ALBANI, F ^{[1
]}

RIVA, R ^{[1
]}

CONTIN, M ^{[1
]}

BARUZZI, A ^{[1
]}

机构：

[1] UNIV BOLOGNA,INST CLIN NEUROL,NEUROPHARMACOL LAB,I-40126 BOLOGNA,ITALY

来源：

THERAPEUTIC DRUG MONITORING | 1992年 / 14卷 / 06期

关键词：

CARBAMAZEPINE; EPILEPSY; CHILDREN;

D O I：

10.1097/00007691-199212000-00003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The effect of aging on carbamazepine (CBZ) plasma level/dose ratio was evaluated retrospectively in 15 children who were receiving CBZ monotherapy and who were followed up for at least 3 years. Subjects of the study were selected from a population of roughly 4,500 patients attending our therapeutic drug monitoring service during a 12-year period. Results showed that the CBZ plasma level/dose ratio increases within subject during childhood, in agreement with data obtained in between-patient studies. However, the increase is not linear with age, the greatest modifications being observed between 9 and 13 years of age. Weight gain alone does not seem to explain this finding, implicating the involvement of complex physiological changes occurring during puberty.

引用

页码：457 / 460

页数：4

共 15 条

[1] CARBAMAZEPINE PLASMA-LEVELS IN CHILDREN AND ADULTS - INFLUENCE OF AGE, DOSE, AND ASSOCIATED THERAPY [J].

BATTINO, D ;

BOSSI, L ;

CROCI, D ;

FRANCESCHETTI, S ;

GOMENI, C ;

MOISE, A ;

VITALI, A .

THERAPEUTIC DRUG MONITORING, 1980, 2 (04) :315-322

[2] CLINICAL PHARMACOKINETICS AND PHARMACOLOGICAL EFFECTS OF CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE - AN UPDATE [J].

BERTILSSON, L ;

TOMSON, T .

CLINICAL PHARMACOKINETICS, 1986, 11 (03) :177-198

[3] CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE SERUM CONCENTRATIONS IN EPILEPTIC CHILDREN [J].

FURLANUT, M ;

MONTANARI, G ;

BONIN, P ;

CASARA, GL .

JOURNAL OF PEDIATRICS, 1985, 106 (03) :491-495

[4] EFFECT OF DOSAGE FREQUENCY OF CARBAMAZEPINE ON DRUG SERUM LEVELS IN EPILEPTIC PATIENTS [J].

GHOSE, K ;

FRY, DE ;

CHRISTFIDES, JA .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 24 (03) :375-381

[5] FACTORS INFLUENCING PLASMA-LEVEL DOSE RATIOS OF CARBAMAZEPINE AND ITS MAJOR METABOLITES IN EPILEPTIC CHILDREN [J].

HARTLEY, R ;

LUCOCK, MD ;

NG, PC ;

FORSYTHE, WI ;

MCLAIN, B ;

BOWMER, CJ .

THERAPEUTIC DRUG MONITORING, 1990, 12 (05) :438-444

[6] DOSE-DEPENDENCY OF THE RATIO BETWEEN CARBAMAZEPINE SERUM LEVEL AND DOSAGE IN PATIENTS WITH EPILEPSY [J].

KUMPS, AH .

THERAPEUTIC DRUG MONITORING, 1981, 3 (03) :271-274

[7]

LINDAY LA, 1991, DEV PHARMACOL THERAP, V4, P194

[8]

PERUCCA E, 1989, CLIN PHARMACOKINET, V5, P576

[9] SERUM CONCENTRATIONS OF CARBAMAZEPINE AND ITS EPOXIDE AND DIOL METABOLITES IN EPILEPTIC PATIENTS - THE INFLUENCE OF DOSE AND COMEDICATION [J].

RAMBECK, B ;

MAY, T ;

JUERGENS, U .

THERAPEUTIC DRUG MONITORING, 1987, 9 (03) :298-303

[10] FREE AND TOTAL SERUM CONCENTRATIONS OF CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE IN INFANCY AND CHILDHOOD [J].

RIVA, R ;

CONTIN, M ;

ALBANI, F ;

PERUCCA, E ;

LAMONTANARA, G ;

BARUZZI, A .

EPILEPSIA, 1985, 26 (04) :320-322

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