A WITHIN-SUBJECT ANALYSIS OF CARBAMAZEPINE DISPOSITION RELATED TO DEVELOPMENT IN CHILDREN WITH EPILEPSY

被引：11

作者：

ALBANI, F ^{[1
]}

RIVA, R ^{[1
]}

CONTIN, M ^{[1
]}

BARUZZI, A ^{[1
]}

机构：

[1] UNIV BOLOGNA,INST CLIN NEUROL,NEUROPHARMACOL LAB,I-40126 BOLOGNA,ITALY

来源：

THERAPEUTIC DRUG MONITORING | 1992年 / 14卷 / 06期

关键词：

CARBAMAZEPINE; EPILEPSY; CHILDREN;

D O I：

10.1097/00007691-199212000-00003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The effect of aging on carbamazepine (CBZ) plasma level/dose ratio was evaluated retrospectively in 15 children who were receiving CBZ monotherapy and who were followed up for at least 3 years. Subjects of the study were selected from a population of roughly 4,500 patients attending our therapeutic drug monitoring service during a 12-year period. Results showed that the CBZ plasma level/dose ratio increases within subject during childhood, in agreement with data obtained in between-patient studies. However, the increase is not linear with age, the greatest modifications being observed between 9 and 13 years of age. Weight gain alone does not seem to explain this finding, implicating the involvement of complex physiological changes occurring during puberty.

引用

页码：457 / 460

页数：4

共 15 条

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