DEGRADATION OF VITRONECTIN BY MATRIX METALLOPROTEINASE-1, METALLOPROTEINASE-2, METALLOPROTEINASE-3, METALLOPROTEINASE-7 AND METALLOPROTEINASE-9

被引：56

作者：

IMAI, K

SHIKATA, H

OKADA, Y

机构：

[1] KANAZAWA UNIV, CANC RES INST, DEPT MOLEC IMMUNOL & PATHOL, KANAZAWA, ISHIKAWA 920, JAPAN

[2] MEIKAI UNIV, SCH DENT, DEPT ORAL PATHOL, SAKADO, SAITAMA 35002, JAPAN

来源：

FEBS LETTERS | 1995年 / 369卷 / 2-3期

关键词：

VITRONECTIN; MATRIX METALLOPROTEINASE; DEGRADATION; KINETICS;

D O I：

10.1016/0014-5793(95)00752-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The susceptibility of vitronectin (Vn) purified from human plasma to digestion by matrix metalloproteinases (MMPs) was examined. MMP-2, -3, -7 and -9 except for MMP-1 degraded Vn into multiple fragments. MMP-7 showed the highest activity to the substrate among these MMPs, digesting 8-, 30-and 44-fold more preferentially than MMP-2, -3 and -9, respectively. These data suggest that MMP-2, -3, -7 and -9 may be responsible for the pathological degradation and/or normal turnover of Vn.

引用

页码：249 / 251

页数：3

共 21 条

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