STEREOCHEMISTRY OF MANNICH BASES .2. STEREOSPECIFIC SYNTHESIS AND ABSOLUTE CONFIGURATION OF DIASTEREOISOMERIC 1-PHENYL-1,2-DIMETHYL-3-DIMETHYLAMINO-PROPAN-1-OLS

During the stereospecific synthesis of diastereoisomeric (+)-1-phenyl-1,2-dimethyl-3-dimethyl-amino-propan-1-ols (III and IV), obtained by reaction of suitable Grignard reagents on α-methyl-β-dimethylamino-propiophenone (I) or on 3-methyl-4-dimethylamino-butan-2-one (II) respectively, the absolute configuration of (-)-amino-alcohol (III) was shown to be 1R, 2S. It was also established that (-)-amino-alcohol (IV) has the 1S, 2S configuration. © 1969.