PP60C-SRC PROTEIN-KINASE ACTIVITY IN HUMAN GASTRIC CARCINOMAS

被引：36

作者：

TAKEKURA, N ^{[1
]}

YASUI, W ^{[1
]}

YOSHIDA, K ^{[1
]}

TSUJINO, T ^{[1
]}

NAKAYAMA, H ^{[1
]}

KAMEDA, T ^{[1
]}

YOKOZAKI, H ^{[1
]}

NISHIMURA, Y ^{[1
]}

ITO, H ^{[1
]}

TAHARA, E ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT PATHOL 1,1-2-3 KASUMI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 05期

关键词：

D O I：

10.1002/ijc.2910450510

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined pp60c‐src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c‐src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c‐src kinase activity in tumor tissues than in corresponding normal mucosa. However, the levels of expression ofpp60c‐src detected by Western blotting were not always consistent with the activities of pp60c‐src protein kinase. These findings suggest that the increase in pp60c‐src protein kinase activity might be brought about by post‐translational changes. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：847 / 851

页数：5

共 26 条

[21] COEXPRESSION OF PLATELET-DERIVED GROWTH-FACTOR (PDGF) A-CHAIN AND PDGF RECEPTOR GENES IN HUMAN GASTRIC CARCINOMAS [J].

TSUDA, T ;

YOSHIDA, K ;

TSUJINO, T ;

NAKAYAMA, H ;

KAJIYAMA, G ;

TAHARA, E .

JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (09) :813-817

[22] STRUCTURE OF THE RECEPTOR FOR PLATELET-DERIVED GROWTH-FACTOR HELPS DEFINE A FAMILY OF CLOSELY RELATED GROWTH-FACTOR RECEPTORS [J].

YARDEN, Y ;

ESCOBEDO, JA ;

KUANG, WJ ;

YANGFENG, TL ;

DANIEL, TO ;

TREMBLE, PM ;

CHEN, EY ;

ANDO, ME ;

HARKINS, RN ;

FRANCKE, U ;

FRIED, VA ;

ULLRICH, A ;

WILLIAMS, LT .

NATURE, 1986, 323 (6085) :226-232

[23]

YASUI W, 1985, CANCER RES, V45, P1565

[24]

YASUI W, 1985, JPN J CANCER RES, V76, P1168

[25] INTERACTION BETWEEN EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN PROGRESSION OF HUMAN GASTRIC-CARCINOMA [J].

YASUI, W ;

HATA, J ;

YOKOZAKI, H ;

NAKATANI, H ;

OCHIAI, A ;

ITO, H ;

TAHARA, E .

INTERNATIONAL JOURNAL OF CANCER, 1988, 41 (02) :211-217

[26]

YASUI W, 1988, CANCER RES, V48, P137

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