FLUVIRUCIN-A1, FLUVIRUCIN-A2, FLUVIRUCIN-B1, FLUVIRUCIN-B2, FLUVIRUCIN-B3, FLUVIRUCIN-B4, AND FLUVIRUCIN-B5, NEW ANTIBIOTICS ACTIVE AGAINST INFLUENZA-A VIRUS .1. PRODUCTION, ISOLATION, CHEMICAL-PROPERTIES AND BIOLOGICAL-ACTIVITIES

Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2,6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3,6-dideoxy-L-talose or 3-amino-3,6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.