FLUVIRUCIN-A1, FLUVIRUCIN-A2, FLUVIRUCIN-B1, FLUVIRUCIN-B2, FLUVIRUCIN-B3, FLUVIRUCIN-B4, AND FLUVIRUCIN-B5, NEW ANTIBIOTICS ACTIVE AGAINST INFLUENZA-A VIRUS .2. STRUCTURE DETERMINATION

被引：51

作者：

NARUSE, N

TSUNO, T

SAWADA, Y

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 07期

关键词：

D O I：

10.7164/antibiotics.44.741

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of structurally related antiviral antibiotics, fluvirucins A1, A2, B1, B2, B3, B4 and B5 have been isolated from the fermentation broths of five unidentified actinomycete isolates. Based on spectroscopic analysis, partial degradation experiments and C-13-enriched acetic acid-fed biosynthetic studies, their structures were elucidated to be 2,6,10-trialkyl-3(or 9)-aminoglycosyl-13-tridecanelactams.

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页码：741 / 755

页数：15

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