AMYGDALOID KINDLING BY REPEATED FOCAL N-METHYL-D-ASPARTATE ADMINISTRATION - COMPARISON WITH ELECTRICAL KINDLING

被引：32

作者：

CROUCHER, MJ ^{[1
]}

COTTERELL, KL ^{[1
]}

BRADFORD, HF ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM,LONDON SW7 2AZ,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 286卷 / 03期

关键词：

KINDLING; NMDA (N-METHYL-D-ASPARTATE); SEIZURE; EPILEPSY; EXCITATORY AMINO ACID; AMYGDALA;

D O I：

10.1016/0014-2999(95)00459-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Limbic seizures were kindled by repeated, daily intra-amygdaloid microinjections of N-methyl-D-aspartate (NMDA; 2 nmol). The seizures, and accompanying afterdischarges, closely resembled those seen following electrical kindling of the amygdala. As with electrical kindling, co-administration of the competitive NMDA receptor antagonist DL-2-amino-7-phosphonoheptanoic acid (AP7; 70 nmol) prevented the development of seizure activity. NMDA-induced kindling was durable, lasting at least 1 month, and showed positive transfer to electrical kindling. Fully kindled seizures were inhibited by co-administration of the potent NMDA receptor antagonist DL-[E]-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849) with the agonist. These results strongly support a role for NMDA receptors in kindling epileptogenesis.

引用

页码：265 / 271

页数：7