TAU IN PAIRED HELICAL FILAMENTS IS FUNCTIONALLY DISTINCT FROM FETAL TAU - ASSEMBLY INCOMPETENCE OF PAIRED HELICAL FILAMENT-TAU

被引：214

作者：

YOSHIDA, H ^{[1
]}

IHARA, Y ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,INST BRAIN RES,DEPT NEUROPATHOL,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF NEUROCHEMISTRY | 1993年 / 61卷 / 03期

关键词：

ALZHEIMERS DISEASE; PAIRED HELICAL FILAMENTS; PAIRED HELICAL FILAMENT-TAU; FETAL-TAU; PHOSPHORYLATION; MICROTUBULES;

D O I：

10.1111/j.1471-4159.1993.tb03642.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tau in paired helical filaments (PHF-tau) and fetal tau share several phosphorylated epitopes, as revealed by several phosphorylation-dependent PHF monoclonals. We have asked whether there is any difference between the two molecules in tubulin assembly-promoting activity and found that PHF-tau is almost assembly incompetent, whereas fetal tau is low in this activity but still assembly competent. This indicates that despite substantial similarities in immunoreactivities, PHF-tau and fetal tau are quite distinct from each other in function.

引用

页码：1183 / 1186

页数：4