THE SRY GENE

被引：14

作者：

HAWKINS, JR

机构：

[1] Department of Genetics, Cambridge University, Cambridge

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1993年 / 4卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/1043-2760(93)90075-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SRY was identified in an attempt to clone the mammalian testis-determining factor. Evidence in the form of sex-reversing mutations and mouse transgenesis experiments indicates that SRY is the testis-determining factor. The cloning of this gene marks the end of the beginning of our understanding of sex determination. This review covers the structure of the SRY gene and its RNA transcripts, along with evidence equating SRY with the mammalian testis-determining factor, its evolution, and biochemical aspects of the SRY protein.

引用

收藏

页码：328 / 332

页数：5

相关论文

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