MORTALITY OF INFANTS LESS-THAN-6 MO OF AGE SUPPLEMENTED WITH VITAMIN-A - A RANDOMIZED, DOUBLE-MASKED TRIAL IN NEPAL

被引：109

作者：

WEST, KP

KATZ, J

SHRESTHA, SR

LECLERQ, SC

KHATRY, SK

PRADHAN, EK

ADHIKARI, R

WU, LSF

POKHREL, RP

SOMMER, A

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,CTR HUMAN NUTR,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DANA CTR PREVENT OPHTHALMOL,BALTIMORE,MD 21205

[3] NNIPS,KATMANDU,NEPAL

[4] NATL SOC PREVENT BLINDNESS,KATMANDU,NEPAL

[5] TRIBHUVAN UNIV,DEPT PEDIAT,KATMANDU,NEPAL

[6] TRIBHUVAN UNIV,KANTI CHILDRENS HOSP,KATMANDU,NEPAL

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 62卷 / 01期

关键词：

VITAMIN-A; SUPPLEMENTATION; INFANT MORTALITY; VERBAL AUTOPSY; INTOLERANCE;

D O I：

10.1093/ajcn/62.1.143

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of supplementing 11 918 infants < 1 ma and 1-5 mo of age with vitamin A (15000 and 30000 mu g retinol equivalents or 50000 and 100000 IU, respectively) or a placebo on subsequent 4-mo mortality was assessed in a randomized, double-masked community trial in the rural plains of Nepal. There were 130 deaths (51.6/1000 child-y) in the control group and 150 deaths (57.1/1000 child-y) in the vitamin A group, yielding a relative risk of 1.11 (95% CI: 0.86, 1.42), which is indicative of no overall effect on early infant mortality. There was a tendency for the relative risk of mortality among vitamin A recipients to rise with improved nutritional status. These results suggest that distribution of a large oral dose of vitamin A to infants < 5-6 mo of age may not benefit short-term survival. This is in contrast with the results of trials in which older infants and children in this same population were supplemented.

引用

页码：143 / 148

页数：6

共 41 条

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