MORTALITY OF INFANTS LESS-THAN-6 MO OF AGE SUPPLEMENTED WITH VITAMIN-A - A RANDOMIZED, DOUBLE-MASKED TRIAL IN NEPAL

被引：109

作者：

WEST, KP

KATZ, J

SHRESTHA, SR

LECLERQ, SC

KHATRY, SK

PRADHAN, EK

ADHIKARI, R

WU, LSF

POKHREL, RP

SOMMER, A

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,CTR HUMAN NUTR,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DANA CTR PREVENT OPHTHALMOL,BALTIMORE,MD 21205

[3] NNIPS,KATMANDU,NEPAL

[4] NATL SOC PREVENT BLINDNESS,KATMANDU,NEPAL

[5] TRIBHUVAN UNIV,DEPT PEDIAT,KATMANDU,NEPAL

[6] TRIBHUVAN UNIV,KANTI CHILDRENS HOSP,KATMANDU,NEPAL

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1995年 / 62卷 / 01期

关键词：

VITAMIN-A; SUPPLEMENTATION; INFANT MORTALITY; VERBAL AUTOPSY; INTOLERANCE;

D O I：

10.1093/ajcn/62.1.143

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of supplementing 11 918 infants < 1 ma and 1-5 mo of age with vitamin A (15000 and 30000 mu g retinol equivalents or 50000 and 100000 IU, respectively) or a placebo on subsequent 4-mo mortality was assessed in a randomized, double-masked community trial in the rural plains of Nepal. There were 130 deaths (51.6/1000 child-y) in the control group and 150 deaths (57.1/1000 child-y) in the vitamin A group, yielding a relative risk of 1.11 (95% CI: 0.86, 1.42), which is indicative of no overall effect on early infant mortality. There was a tendency for the relative risk of mortality among vitamin A recipients to rise with improved nutritional status. These results suggest that distribution of a large oral dose of vitamin A to infants < 5-6 mo of age may not benefit short-term survival. This is in contrast with the results of trials in which older infants and children in this same population were supplemented.

引用

页码：143 / 148

页数：6

共 41 条

[21]

Katz D., Baptista J., Azen S.P., Pike M.C., Obtaining confidence intervals for the risk ratio in cohort studies, Biometrics, 34, pp. 469-474, (1978)

[22]

Katz J., Zeger S.L., Estimation of design effects in cluster surveys, Ann Epidemiol, 4, pp. 295-301, (1994)

[23]

Khatry S.K., West Jr. K.P., Katz J., Et al., Epidemiology of xerophthalmia in Nepal: A pattern of household poverty, childhood illness and mortality, Arch Ophthalmol, 113, pp. 425-429, (1995)

[24]

Tarwotjo I., Sommer A., Soegiharto T., Dietary practices and xerophthalmia among Indonesian children, Am J Clin Nutr, 35, pp. 574-581, (1982)

[25]

West K.P., Chirambo M., Katz J., Sommer A., Breast-feeding, weaning patterns, and the risk of xerophthalmia. A case-control study in Southern Malawi, Am J Clin Nutr, 44, pp. 690-697, (1986)

[26]

Mahalanabis D., Breast feeding and vitamin A deficiency among children attending a diarrhoea treatment centre in Bangladesh: A casecontrol study, Br Med J, 303, pp. 493-496, (1991)

[27]

Pathwardan V.N., Kamel W.W., Pharaon H., Studies on Vitamin A Deficiency in Infants and Young Children in Jordan. Part II. A Pilot Trial of Vitamin A Prophylaxis in Jordanian Infants (February, 1965-August, 1966), (1966)

[28]

Clausen S.W., The effects of moderate deficiency of vitamins, Bull N Y Acad Med, 10, pp. 471-482, (1934)

[29]

Sommer A., Loewenstein M., Nutritional status and mortality. A prospective validation of the QUAC stick, Am J Clin Nutr, 28, pp. 287-292, (1975)

[30]

Pelletier D.L., The relationship between child anthropometry and mortality in developing countries: Implications for policy, programs and future research, J Nutr, 124, (1994)

← 1 2 3 4 5 →