AGING AND SEX INFLUENCE THE PERMEABILITY OF THE BLOOD-BRAIN-BARRIER IN THE RAT

被引：33

作者：

SAIJA, A

PRINCI, P

DAMICO, N

DEPASQUALE, R

COSTA, G

机构：

[1] UNIV MESSINA, CTR INTERDIPARTIMENTALE INFORMAZ FARMACO TOSSICOL, I-98100 MESSINA, ITALY

[2] UNIV CAMERINO, SCH PHARM, INST PHARMACOL, I-62032 CAMERINO, ITALY

来源：

LIFE SCIENCES | 1990年 / 47卷 / 24期

关键词：

D O I：

10.1016/0024-3205(90)90157-M

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of the present study was to investigate the existence of aging- and sex-related alterations in the permeability of the blood-brain barrier (BBB) in the rat, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-α-aminoisobutyric acid. We observed that: a) the permeability of the BBB significantly increased within the frontal and temporo-parietal cortex, hypothalamus and cerebellum in 28-30 week old rats, in comparison with younger animals; b) in several brain areas of female intact rats higher Ki values (even though not significantly different) were calculated at oestrus than at proestrus; c) in 1-week ovariectomized rats there was a marked increase of Ki values at the level of the frontal, temporo-parietal and occipital cortex, cerebellum and brain-stem. One can speculate that aging- and sex-related alterations in the permeability of the BBB reflect respectively changes in brain neurochemical system activity and in plasma steroid hormone levels. © 1990.

引用

页码：2261 / 2267

页数：7

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