ALLYLIC ESTERS AS POTENTIAL ANTI-TUMOR AGENTS - DERIVATIVES AND ANALOGS OF 2,3-BIS(HYDROXYMETHYL)-7-OXABICYCLO[2.2.1]HEPT-2-ENE

被引：12

作者：

ANDERSON, WK

DEWEY, RH

MULUMBA, B

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, Amherst

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 10期

关键词：

D O I：

10.1021/jm00196a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Derivatives and analogues of 2, 3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2, 3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2, 5-diene-5, 6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93% inhibition at 10-6 M). None of the compounds showed significant reproducible in vivo antileukemic activity. © 1979, American Chemical Society. All rights reserved.

引用

页码：1270 / 1272

页数：3

共 31 条

[1] VINYLOGOUS CARBINOLAMINE TUMOR INHIBITORS .4. ANTI-LEUKEMIC ACTIVITY OF DERIVATIVES OF 1,2-DIMETHYL-3,4-BIS(HYDROXYMETHYL)-5-PHENYLPYRROLE BIS(N-METHYLCARBAMATE)
ANDERSON, WK
HALAT, MJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (08) : 977 - 980
[2] ANTILEUKEMIC ACTIVITY OF DERIVATIVES OF 1-PHENYL-2,5-DIMETHYL-3,4-BIS(HYDROXYMETHYL)PYRROLE BIS(N-METHYLCARBAMATE)
ANDERSON, WK
COREY, PF
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (12) : 1691 - 1694
[3] SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF CYTOTOXIC EPOXIDE DERIVATIVES OF 7-OXABICYCLO[2.2.1]HEPTANE
ANDERSON, WK
DEWEY, RH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (02) : 306 - 308
[4] SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF 5-SUBSTITUTED 2,3-DIHYDRO-6,7-BIS(HYDROXYMETHYL)-1H-PYRROLIZINE DIESTERS
ANDERSON, WK
COREY, PF
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (06) : 812 - 818
[5] PHOTOELECTRON SPECTRA OF CYCLIC ETHERS
BAIN, AD
BUNZLI, JC
FROST, DC
WEILER, L
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (01) : 291 - 292
[6] PREPARATION AND ACTIVITY OF 4'-THIO DERIVATIVES OF SOME 6-SUBSTITUTED PURINE NUCLEOSIDES
BOBEK, M
WHISTLER, RL
BLOCK, A
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) : 411 - &
[7] BULL LB, 1968, PYRROLIZINE ALKALOID
[8] SOME ANTINEOPLASTIC ANTIBIOTICS
CHENG, CC
ZEECHENG, K
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (04) : 485 - +
[9] POLYMERIZATION AND RING STRAIN IN BRIDGED BICYCLIC COMPOUNDS
HALL, HK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (23) : 6412 - 6420
[10] ANTITUMOR AGENTS .21. PROPOSED MECHANISM FOR INHIBITION OF CANCER GROWTH BY TENULIN AND HELENALIN AND RELATED CYCLOPENTENONES
HALL, IH
LEE, KH
MAR, EC
STARNES, CO
WADDELL, TG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (03) : 333 - 337

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