PRODUCTION OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA IN-VITRO IS REDUCED IN WHOLE-BLOOD OF SEVERELY MALNOURISHED CHILDREN

被引：49

作者：

DOHERTY, JF

GOLDEN, MHN

REMICK, DG

GRIFFIN, GE

机构：

[1] UNIV W INDIES, TROP METAB RES UNIT, KINGSTON 7, JAMAICA

[2] ST GEORGE HOSP, SCH MED, COMMUNICABLE DIS UNIT, LONDON, ENGLAND

[3] UNIV ABERDEEN, DEPT MED, ABERDEEN, SCOTLAND

[4] UNIV MICHIGAN, SCH MED, DEPT PATHOL, ANN ARBOR, MI USA

来源：

CLINICAL SCIENCE | 1994年 / 86卷 / 03期

基金：

英国惠康基金;

关键词：

CYTOKINE PRODUCTION; INTERLEUKIN-6; PROTEIN-ENERGY MALNUTRITION; TUMOR NECROSIS FACTOR;

D O I：

10.1042/cs0860347

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Cytokine production in vitro was assessed in 16 malnourished children, before and after nutritional recovery. 2. Tumour necrosis factor-alpha and interleukin-6 were measured in whole blood after lipopolysaccharide stimulation. 3. The total amount of both cytokines was significantly less after 24 h incubation among malnourished children when compared with the same children after nutritional rehabilitation. 4. Cytokine production in vitro is impaired in severely malnourished children.

引用

页码：347 / 351

页数：5

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