ENZYMES IN ORGANIC-SYNTHESIS .7. SYNTHESIS OF DIHYDROXYACETONE PHOSPHATE (AND ISOSTERIC ANALOGS) BY ENZYMATIC OXIDATION - SUGARS FROM GLYCEROL

被引:81
作者
FESSNER, WD [1 ]
SINERIUS, G [1 ]
机构
[1] UNIV FREIBURG,INST ORGAN CHEM & BIOCHEM,D-79104 FREIBURG,GERMANY
来源
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 02期
关键词
D O I
10.1002/anie.199402091
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The combination of enzymes glycerol phosphate oxidase and catalase allows the efficient preparative oxidation of glycerol phosphate 1 (X = O) with elemental oxygen which yields dihydroxyacetone phosphate 2 (X = O). Phosphate 2 can be added to various aldehydes in a one‐flask, enzyme‐catalyzed reaction to furnish 3 (X = O). Isosteric analogues of glycerol phosphate 1 (X = CH2, NH, S) can be converted into the corresponding adducts 3. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
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页码:209 / 212
页数:4
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