FUNCTIONAL SYNERGISM BETWEEN PUTATIVE GAMMA-AMINOBUTYRATE-CONTAINING NEURONS AND PYRAMIDAL NEURONS IN PREFRONTAL CORTEX

被引：241

作者：

WILSON, FAW ^{[1
]}

SCALAIDHE, SPO ^{[1
]}

GOLDMANRAKIC, PS ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,NEUROBIOL SECT,NEW HAVEN,CT 06510

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 09期

关键词：

FAST SPIKE; MONKEY; MEMORY; INTERNEURONS; VISION;

D O I：

10.1073/pnas.91.9.4009

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The responses of putative gamma-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that gamma-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with gamma-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of gamma-aminobutyratergic mechanisms in cognition.

引用

页码：4009 / 4013

页数：5

共 32 条

[21] INHIBITORY EFFECTS OF VENTRAL TEGMENTAL AREA STIMULATION ON THE ACTIVITY OF PREFRONTAL CORTICAL-NEURONS - EVIDENCE FOR THE INVOLVEMENT OF BOTH DOPAMINERGIC AND GABAERGIC COMPONENTS [J].