GENETIC ORGANIZATION AND COMPLETE SEQUENCE OF THE PROTEUS-MIRABILIS PMF FIMBRIAL OPERON

被引：22

作者：

MASSAD, G ^{[1
]}

MOBLEY, HLT ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21201

来源：

GENE | 1994年 / 150卷 / 01期

关键词：

VIRULENCE DETERMINANT; URINARY TRACT INFECTION; CHAPERONIN; UROPATHOGEN; PYELONEPHRITIS;

D O I：

10.1016/0378-1119(94)90866-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Proteus mirabilis, commonly associated with urinary tract infection, pyelonephritis and bacteremia, produces a number of fimbriae, including PMF P. mirabilis fimbriae). Genes encoding PMF were isolated and the complete nucleotide (nt) sequence was determined. The pmf gene cluster, encoded by 5655 bp, predicts five polypeptides: PmfA (18921 Da), PmfC (93 107 Da), PmfD (28208 Da), PmfE (38875 Da) and PmfF (19661 Da). PmfA. PmfC, PmfD and PmfF share > 25% amino acid (aa) sequence identity with gene products of the pap, mrp and sfa fimbrial gene clusters. PmfE shares no similarity with any polypeptide in the SwissProt database. No regulatory gene(s) or regulatory elements were evident in the sequence. The pmf cluster shares common features with other enteric fimbrial gene clusters, but also displays features that are unique.

引用

页码：101 / 104

页数：4

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