ERYTHROMYCIN LAURYL SULFATE IN COMBINATION WITH TRETINOIN IN THE TOPICAL TREATMENT OF ACNE-VULGARIS - A MULTICENTER DOUBLE-BLIND CLINICAL-TRIAL

被引:3
作者
FONSECA, E
FERRANDIZ, C
CAMARASA, JG
OLMOS, L
DELPINO, J
RODRIGUEZ, T
SANMARTIN, JC
ROMAN, P
ASIN, M
SAMBRICIO, F
TORMO, JL
机构
[1] HOSP LA PAZ,DEPT DERMATOL,MADRID,SPAIN
[2] HOSP GERMANS TRIAS & PUJOL,DEPT DERMATOL,BADALONA,SPAIN
[3] HOSP MARE DEU ESPERANCA,DEPT DERMATOL,BARCELONA,SPAIN
[4] HOSP CLIN UNIV,DEPT DERMATOL,MADRID,SPAIN
[5] HOSP CENT CRUZ ROJA SAN JOSE & ST ADELA,DEPT DERMATOL,MADRID,SPAIN
[6] HOSP NUESTRA SENORA COVADONGA,DEPT DERMATOL,OVIEDO,SPAIN
[7] HOSP GEN,DEPT DERMATOL,ALACANT,SPAIN
[8] HOSP SAN JUAN DIOS,VALENCIA,SPAIN
关键词
TOPICAL ERYTHROMYCIN; TRETINOIN; ACNE VULGARIS;
D O I
10.3109/09546639509080591
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Topical erythromycin and tretinoin (TRT) are estabished as effective treatments for acne vulgaris, Nevertheless, studies on the efficacy and safety of the combination of erythromycin and tretinoin are scarce, In a multicentre double-blind study, 272 patients were selected and randomized to one of the following three groups: (1) 2.75% erythromycin lauryl sulphate (ELS) (equivalent to 2% erythromycin base) applied in the morning and at night (n = 88); (2) placebo applied in the morning and 0.05% TRT at night (n = 92); (3) placebo applied in the morning and ELS/TRT at night, Treatments were applied for 10 weeks, Clinical assessments were performed at 0, 5 and 10 weeks, ELS/TRT was significantly better than ELS alone in the reduction of total (P < 0.001), open (P < 0.001) and closed comedones (P < 0.025), The efficacy of ELS/TRT was significantly better than that of TRT alone in the reduction of inflammatory lesions (P < 0.01) and pustules (P < 0.025), The mean grade of acne severity at week 10 was significantly lower with ELS/TRT than with ELS (P < 0.05), No serious side-effects were reported, Mild irritative effects were observed in patients treated with TRT, ELS/TRT applied once daily is therefore an effective and well-tolerated treatment for acne vulgaris, This combination significantly enhances the comedolytic action of TRT and the antiinflammatory effect of ELS.
引用
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页码:47 / 50
页数:4
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