CREATINE-PHOSPHOKINASE LEVELS IN THE NEWBORN AND THEIR USE IN SCREENING FOR DUCHENNE MUSCULAR-DYSTROPHY

被引：37

作者：

DRUMMOND, LM

机构：

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1979年 / 54卷 / 05期

关键词：

D O I：

10.1136/adc.54.5.362

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The PKU sample, if taken after the 3rd day, is suitable for Duchenne muscular dystrophy screening using creatine phosphokinase (CPK) levels. 101 infants (53 girls and 48 boys) had CPK levels measured on filter paper blood specimens taken by heel prick on the 1st and 4th days of life. The method used was that described by Zellweger and Antonik (1975). The CPK levels were markedly raised on the 1st day of life but by the 4th day they had reduced to within 3 times the upper limit of the normal range for adults. 10 000 boys were then screened for Duchenne muscular dystrophy using the PKU sample, and 2 cases were found.

引用

页码：362 / 366

页数：5