PROLINE 4-HYDROXYLASE - STEREOCHEMICAL COURSE OF THE REACTION

被引：21

作者：

BALDWIN, JE ^{[1
]}

FIELD, RA ^{[1
]}

LAWRENCE, CC ^{[1
]}

MERRITT, KD ^{[1
]}

SCHOFIELD, CJ ^{[1
]}

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)60161-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereochemical course of the hydroxylation of (S)-proline by proline 4-hydroxylase from Streptomyces griseoviridus has been investigated using (2S, 4S)-[4-H-2(1)]-proline and (2S, 4R)-[4-H-2(1)]-proline and found to occur with retention of stereochemistry at C-4 of proline.

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页码：7489 / 7492

页数：4

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