STUDIES ON THE STEREOSPECIFICITY OF THE CLAVAMINIC ACID SYNTHASE CATALYZED HYDROXYLATION REACTION

被引：23

作者：

BALDWIN, JE

MERRITT, KD

SCHOFIELD, CJ

ELSON, SW

BAGGALEY, KH

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

[2] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 16期

关键词：

D O I：

10.1039/c39930001301

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incubation of (2S,3S)-5-guanidino[2,3-H-2(2)]-2-(2'-oxoazetidin-1'-yl)pentanoic acid and (2S,3R)-5-guanidino-[3-H-2(1)]-2-(2'-oxoazetidin-1'-yl)pentanoic acid with clavaminic acid synthase resulted in highly stereospecific hydroxylation at C-3, with removal of the pro-R hydrogen or deuterium, respectively.

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页码：1301 / 1302

页数：2

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