THE DYSTROPHIN CONNECTION - ATP

被引：17

作者：

BONSETT, CA

RUDMAN, A

机构：

[1] Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46223, Emerson Hall 125

来源：

MEDICAL HYPOTHESES | 1992年 / 38卷 / 02期

关键词：

D O I：

10.1016/0306-9877(92)90087-S

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Clinical evidence is presented supporting the hypothesis that the metabolic abnormality in the dystrophin-defective muscular dystrophies (DMD and BMD) involves the ATP pathway. Objective laboratory data show corrective trends in the abnormal values of parameters relating to creatine and calcium metabolism (ATP) by use of glucagon-stimulated c-AMP and by use of synthetically produced adenylosuccinic acid (ASA). Disease accelerating mechanisms as suggested by analysis of the clinical features, and the therapeutic potential of ASA are discussed.

引用

页码：139 / 154

页数：16

共 27 条

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