ATTACHMENT OF MITOCHONDRIA TO INTERMEDIATE FILAMENTS IN ADRENAL-CELLS - RELEVANCE TO THE REGULATION OF STEROID-SYNTHESIS

被引：46

作者：

ALMAHBOBI, G ^{[1
]}

WILLIAMS, LJ ^{[1
]}

HALL, PF ^{[1
]}

机构：

[1] PRINCE WALES HOSP,DEPT ENDOCRINOL,RANDWICK,NSW 2031,AUSTRALIA

来源：

EXPERIMENTAL CELL RESEARCH | 1992年 / 200卷 / 02期

关键词：

D O I：

10.1016/0014-4827(92)90184-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rate of steroid synthesis is regulated by the rate of transport of cholesterol from lipid droplets to mitochondria. We have previously demonstrated that lipid droplets in adrenal cells are tightly attached to intermediate filaments. Here we now show that mitochondria colocalize with intermediate filaments in modified double indirect immunofluorescence and by electron microscopy of extracted adrenal cells. Direct contact between mitochondria and intermediate filaments was established by examination of stereo pairs of electron micrographs from extracted cells. The attachment of both droplets and mitochondria to intermediate filaments suggests possible mechanisms for this form of intracellular transport of cholesterol to mitochondria and hence for the regulation of steroid synthesis. © 1992.

引用

页码：361 / 369

页数：9

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