We predict, on the basis of a model calculation, that an asymmetric Fano-type line shape in the intersubband absorption spectrum will be produced by the electron-LO-phonon interaction in a suitably designed quantum well. The asymmetry parameter q, the broadening Γ, and the frequency shift Δωp in the Fano profile are varied with the change of the quantum-well structure parameters, and q is also altered by the variation of the doping density in the well. © 1995 The American Physical Society.