HYPOGALACTOSYLATION OF IMMUNOGLOBULIN-G SUGAR CHAINS AND ELEVATED SERUM INTERLEUKIN-6 IN CASTLEMANS DISEASE

被引：27

作者：

NAKAO, H ^{[1
]}

NISHIKAWA, A ^{[1
]}

NISHIURA, T ^{[1
]}

KANAYAMA, Y ^{[1
]}

TARUI, S ^{[1
]}

TANIGUCHI, N ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT BIOCHEM,OSAKA 553,JAPAN

来源：

CLINICA CHIMICA ACTA | 1991年 / 197卷 / 03期

关键词：

HYPOGALACTOSYLATION; IGG; OLIGOSACCHARIDE; INTERLEUKIN-6; CASTLEMANS DISEASE;

D O I：

10.1016/0009-8981(91)90142-Y

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Immunoglobulin G (IgG) molecule has two N-linked complex type oligosaccharides, consisting of a mixture of at least 12 different structures. The pattern of these oligosaccharides is fairly constant in healthy individuals. In three patients with Castleman's disease, in whom serum interleukin 6 (IL-6) levels were elevated, agalactosyl species of serum IgG oligosaccharides were markedly increased as compared to those of normal healthy controls. A close relationship between increased IL-6 and altered IgG oligosaccharide structure is suggested.

引用

页码：221 / 228

页数：8

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