EVIDENCE THAT CCKB RECEPTORS MEDIATE THE REGULATION OF EXPLORATORY-BEHAVIOR IN THE RAT

被引：84

作者：

HARRO, J

VASAR, E

机构：

[1] Psychopharmacology Laboratory, Institute of General and Molecular Pathology, Tartu University, SU-202400, 34 Veski Street, Tartu

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 193卷 / 03期

关键词：

CCK RECEPTORS; CCK4; CCK RECEPTOR ANTAGONISTS; EXPLORATORY ACTIVITY; ANXIETY;

D O I：

10.1016/0014-2999(91)90156-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peripheral administration of cholecystokinin tetrapeptide (CCK-4) at non-sedative doses (25-50-mu-g/kg) decreased the exploratory activity of rats in an elevated plus-maze. This effect was antagonized by treatment with CCK receptor antagonists proglumide (1 and 10 mg/kg), lorglumide (0.1 and 1 mg/kg), L 365,260 (10-mu-g/kg) and devazepide (1 mg/kg). The results suggest that the exploratory behaviour of rats can be altered by pharmacological manipulations at CCK-B receptors.

引用

页码：379 / 381

页数：3

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