PARA FLUORINATION BY N-FLUOROBIS[(TRIFLUOROMETHYL)SULFONYL]IMIDE - SYNTHESIS OF 10-BETA-FLUORO-3-OXO-1,4-ESTRADIENE STEROIDS

被引：29

作者：

PENNINGTON, WT ^{[1
]}

RESNATI, G ^{[1
]}

DESMARTEAU, DD ^{[1
]}

机构：

[1] CLEMSON UNIV,HOWARD L HUNTER CHEM LAB,CLEMSON,SC 29629

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 05期

关键词：

D O I：

10.1021/jo00031a038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

When 1,3,5(10)-estratrien-3-ols are treated with N-fluorobis[(trifluoromethyl)sulfonyl]imide in chloroform solution the ortho and para fluorination products are formed. In contrast, when acetic acid is used as a solvent, fluorination in the para position occurs selectively and 10-beta-fluoro-3-oxo-1,4-estradiene derivatives are formed in high yields.

引用

页码：1536 / 1539

页数：4

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