LEVELS, UPTAKE, AND RELEASE OF GLYCINE AND GLUTAMATE IN THE RAT PONTINE RETICULAR-FORMATION

被引：9

作者：

CAMACHOARROYO, I ^{[1
]}

TAPIA, R ^{[1
]}

机构：

[1] NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS,APARTADO POSTAL 70-600,MEXICO CITY 04510,DF,MEXICO

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 05期

关键词：

PONTINE RETICULAR FORMATION; GLYCINE; GLUTAMATE; NEUROTRANSMITTER AMINO ACIDS; UPTAKE AND RELEASE;

D O I：

10.1007/BF00969893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work we have determined the levels of glycine, glutamate, and other amino acids in the rat pontine reticular formation (PRF), in addition to some properties of the uptake and release of labeled glycine and glutamate in slices of this region. Glutamate was the most concentrated amino acid in the PRF, although its content was about half that of the striatum. Surprisingly, glycine levels in the PRF were 3.2-fold higher than in the striatum, whereas GABA content was similar in both regions. The uptake of both glycine and glutamate by PRF slices was strictly Na+-dependent. Their release was stimulated by K+-depolarization, but only the release of glycine was Ca2+-dependent. These findings suggest that glycine is a strong candidate for a neurotransmitter role in the PRF and that glutamate might also play such a role in this region.

引用

页码：463 / 467

页数：5

共 42 条

[1] GABA AND GLYCINE AS PUTATIVE TRANSMITTERS IN SUBCORTICAL PATHWAYS TO THE PONTINE NUCLEI - A COMBINED IMMUNOCYTOCHEMICAL AND RETROGRADE TRACING STUDY IN THE CAT WITH SOME OBSERVATIONS IN THE RAT [J].