ENDOTHELIN-BINDING INHIBITORS, BE-18257A AND BE-18257B .2. STRUCTURE DETERMINATION

被引：21

作者：

NAKAJIMA, S ^{[1
]}

NIIYAMA, K ^{[1
]}

IHARA, M ^{[1
]}

KOJIRI, K ^{[1
]}

SUDA, H ^{[1
]}

机构：

[1] BANYU PHARMACEUT CO LTD,EXPLORATORY RES LABS,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 12期

关键词：

D O I：

10.7164/antibiotics.44.1348

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of novel endothelin-binding inhibitors, BE-18257A and BE-18257B, were elucidated by spectral analyses and chemical studies. Both inhibitors were found to have a cyclic pentapeptide structure containing three D-form amino acid residues, namely, the structures of BE-18257A and BE-18257B were elucidated to be cyclo(-D-Glu-L-Ala-D-Val-L-Leu-D-Trp-) and cyclo(-D-Glu-L-Ala-allo-D-Ile-L-LeU-D-Trp-), respectively.

引用

页码：1348 / 1356

页数：9

共 6 条

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